Barrymore was born Lionel Herbert Blythe in Philadelphia, Pennsylvania, the son of actors Georgiana Drew and Maurice Barrymore (né Blythe). He was the elder brother of Ethel and John Barrymore, the uncle of John Drew Barrymore, and the granduncle (or great-uncle) of Drew Barrymore. Barrymore was raised Roman Catholic. He attended the Episcopal Academy in Philadelphia, Pennsylvania.
Famed actor, composer, artist, author and director. His talents extended to the authoring of the novel "Mr. Cartonwine: A Moral Tale" as well as his autobiography. In 1944, he joined ASCAP, and composed "Russian Dances", "Partita", "Ballet Viennois", "The Woodman and the Elves", "Behind the Horizon", "Fugue Fantasia", "In Memorium", "Hallowe'en", "Preludium & Fugue", "Elegie for Oboe, Orch.", "Farewell Symphony (1-act opera)", "Elegie (piano pieces)", "Rondo for Piano" and "Scherzo Grotesque".