Hedda Hopper was born in Hollidaysburg, Pennsylvania, U.S. , the daughter of David D. (born 1857) and Margaret Miller (born 1856) Furry, who were German Baptist Brethren. Her siblings included Dora Furry (born March 1880); Sherman Furry (born June 1882); Cameron Furry (born September 1887); Edgar Furry (April 20, 1889 - November 1975); Frank M. Furry (born August 1891); and Margaret Furry (born July 1897). On May 8, 1913, she married DeWolf Hopper in New Jersey. They had one child, actor William Hopper, best known for playing Paul Drake in the Perry Mason series. They were divorced in 1922.
Hopper died of double pneumonia at the age of 80 in Cedars of Lebanon Hospital in Hollywood. She is buried at Rose Hill Cemetery, Altoona, Pennsylvania. For her contribution to the motion picture industry, Hopper has a star on the Hollywood Walk of Fame at 6313 1/2 Hollywood Boulevard in Hollywood.