He was born George Miltiades Melachrino in Albany Street, London in 1909. His father was a Greek cigarette manufacturer, and his mother came from Broadway in Worcestershire. At the age of four he was being taught by his stepfather on a miniature violin, and was only thirteen when he made his first public appearance as a solo violinist. Three years later he enrolled at the Trinity College of Music, winning particular praise for his work with strings. He proceeded to master all the instruments of the orchestra, with the exception of the piano and harp. In addition he had a pleasant singing voice, and broadcast from the BBC Studios at Savoy Hill when only eighteen.
Like so many of his contemporaries, Melachrino discovered that his talents were well suited to the demands of the British dance bands which flourished during his youth. In numerous broadcasts and recordings he performed on clarinet, alto and tenor saxophone, violin, viola and as a most competent vocalist. While still in his teens, as early as 1926 he was recording with Geoffrey Gelder and his Kettner’s Five, and in the following years he was employed by Ambrose, Harry Hudson, Jack Jackson, Van Phillips, Rudy Starita, Jay Wilbur, Marius B. Winter and Carroll Gibbons and his Savoy Hotel Orpheans. Gibbons made him one of his ‘star’ vocalists, and his duets with Anne Lenner were especially popular. Examples of his work with this fine ensemble can be heard on Vocalion CDEA6047.
Melachrino was married three times. His first wife and two sons aged 12 and 15 were killed by a flying bomb during the war. Afterwards he devoted much of his time to helping sick children. His second marriage was dissolved. In 1961 he had a son by his third wife, former ballet dancer Noreen Lee.