Pyne was born in Kolkata and grew up in a decaying mansion. He also grew up on stories told by his grandmother --- fold stories, mythological stories, and fairy tales. He spent several evenings in smoky Kolkata cafes discussing communism and Picasso with his friends. "My childhood memories revolve around Kolkata. The sounds and smells of this city fill my being. I love Kolkata." He doesn't remember the first time he started to paint, but does remember the anger that he drew from his family over his decision to become an artist. Pyne, nevertheless, took admission in the Government College of Arts and Crafts, Kolkata. "My first painting was 'Winter's Morning' which showed me and my brother going to school," he recalls. In 1963, he joined the Society for Contemporary Artists. During that period he made small drawings in pen and ink. "I did not have enough money then to buy color," Pyne says.
This was also the period of experimentation. The anger and despair of the 70s fuelled one of the most fruitful periods' in his life as an artist that culminated in works like 'Before the Chariot' and 'The Assassin'. However, sometime in the 80s, he shut himself from the world, driven away by the jealousy and pettiness that the art bazaar arose among his friends. Initially, Pyne painted watercolors and sketches of misty mornings and wayside temples, variously influenced as he was by Walt Disney and the art of Abanindranath Tagore. He counts Hals Rembrandt and Paul Klee as the other influences. His signature style shaped from his own experiences of solitude, alienation, pain, horror and moods of tenderness and serenity comes to surface in each of his works. At times, these images are offshoots of an idea that may have flitted through his mind. At others, they resonate lines from poems that may have made an impression on his mind. The lines are bold, precise, controlled and the drawings that emerge are potent both in form and content. Stripped of color, they convey the architectonic quality in the structuring of the images. Equally devoted to cinema as he is to painting, Pyne has also drawn inspirations from movies made by Fellini and Ingmar Bergman. Today, he is known as the foremost exponents of the Bengal School of art. Ganesh Pyne lives and works out of Kolkata.